Biomedical Flows Simulation & Multiscale Modeling Lab (BioSiMM Lab)

Computational methods are emerging as relevant tools for diagnosing, treating, and quantifying disease progression. However, the translation of these computational methods to the clinic is not yet a reality. The BioSiMM Lab focuses on patient-specific multi-scale modeling and computational fluid dynamics. Our goal is to leverage computational simulations to provide improved patient-specific risk-stratification metrics and enable the design of personalized therapies at a reasonable computational cost. The group's research areas include thrombosis, vascular and microvascular blood flow modeling, transport and drug delivery, and medical device development, emphasizing investigating sex differences in cardiovascular disease.

Faculty

Headshot of Gutiérrez

Noelia Grande Gutiérrez

Assistant Professor, Mechanical Engineering

Courtesy appointment, Biomedical Engineering

Noelia Grande Gutiérrez joined the Department of Mechanical Engineering at Carnegie Mellon University in Fall 2021. Her research group works at the intersection of computational engineering and medicine. The BioSiMM Lab strives to provide new insight into health and disease towards more personalized patient care using computational modeling.

Office
4206 Wean Hall
Email
ngrandeg@andrew.cmu.edu
Google Scholar
Noelia Grande Gutiérrez

Projects

Research Team

Arnav Garcha

Arnav Garcha

Doctorate

Research interests
computational modeling, image-based simulation, coronary hemodynamics, thrombosis modeling
Wenzhuo Xu

Wenzhuo Xu

Doctorate

Co-Advisor
Chris McComb
Research interests
machine learning, deep learning, data-driven acceleration of numerical simulations
Maria Plesia

Maria Plesia

Doctorate

Co-Advisor
Conrad Tucker
Research interests
machine learning, deep learning
Armita Najmi

Armita Najmi

Doctorate

Research interests
computational modeling, uteroplacental and fetal-placental hemodynamics, biotransport phenomena
Lara Abdelmohsen

Lara Abdelmohsen

Doctorate

Co-Advisor
Sossena Wood
Research interests
image-based simulation, cerebral hemodynamics
Yingqi Yue

Yingqi Yue

Masters

Research interests
computational modeling, medical devices

Past students

Undergraduate:

Rohit Garikipati 

Li Fen Frothingham

Zoe Phares

Selected Publications

2021

N. Grande Gutiérrez, T. Sinno, S.L. Diamond. “A 1D-3D hybrid model of patient-specific coronary hemodynamics.Cardiovascular Engineering and Technology (2021)

N. Grande Gutiérrez, M. Alber, A.M. Kahn, Jane C. Burns, M. Mathew, Brian W. McCrindle, A.L. Marsden. ”Computational modeling of blood component transport related to coronary artery thrombosis in Kawasaki disease patients.” PLoS computational biology, Vol. 17 (9) (2021)

N. Grande Gutiérrez, K. N. Shankar, T. Sinno, S.L. Diamond. “Thrombosis and Hemodynamics: external and intrathrombus gradients.Current Opinion in Biomedical Engineering, Vol. 19 (2021)

2019

N. Grande Gutiérrez, M. Mathew, B. McCrindle, J.S. Tran, A.M. Kahn, J.C. Burns, A.L. Marsden. “Hemodynamic variables in aneurysms are associated with thrombotic risk in children with Kawasaki disease.International Journal of Cardiology, Vol. 281 (2019)

2017

N. Grande Gutiérrez, A. Kahn, J.C. Burns, A.L. Marsden. “Computational blood flow simulations in Kawasaki disease patients: Insight into coronary artery aneurysm hemodynamics.Global cardiology science & practice, (3) (2017)

N. Grande Gutiérrez, O. Shirinsky, N.V. Gagarina, G.A. Lyskina, R. Fukazawa, S. Ogawa, J.C. Burns, A.L. Marsden, A.M. Kahn. “Assessment of coronary artery aneurysms caused by Kawasaki disease using transluminal attenuation gradient analysis of computerized tomography angiograms.American Journal of Cardiology, Vol.120 (4) (2017)

2015

B.R. Macias, J.H.K. Liu, N. Grande Gutiérrez, A.R. Hargens. “Intraocular and intracranial pressures during head-down tilt with lower body negative pressure.Aviation, Space, and Environmental Medicine, Vol. 86 (1) (2015)